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CIS & Astrix Guide For Secure AI Agent Environments

4 Dec 2025

CIS & Astrix Guide For Secure AI Agent Environments
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Summary is AI-generated, newsdesk-reviewed
  • CIS, Astrix, and Cequence partner for secure AI and agent system cybersecurity guidance.
  • New guides extend CIS Controls to tackle AI risks like credential exposure and unauthorized connections.
  • Partnership enhances AI ecosystem safety with specialized API, AI agent, and NHI security measures.
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The Center for Internet Security, Inc. (CIS), Astrix Security, and Cequence Security announced a strategic alliance aimed at crafting cybersecurity guidelines tailored to address the risks unique to artificial intelligence (AI) and agentic systems. This effort enhances the established CIS Critical Security Controls by expanding its principles into AI settings, where autonomous decision-making and automated threats present substantial challenges.

The partnership primarily focuses on initiating two CIS Controls companion guides: one dedicated to AI Agent Environments, emphasizing the security of the agent system lifecycle, and another targeting Model Context Protocol (MCP) environments.

Addressing AI-Specific Risks

MCP environments present distinct risks, including credential exposure, unregulated local execution

MCP environments present distinct risks, including credential exposure, unregulated local execution, unapproved third-party connections, and unchecked data flows between models and tools.

These guides are designed to equip organizations with targeted safeguards for environments engaged in the dynamic interaction of MCP agents, tools, and registries with enterprise systems.

“AI presents both tremendous opportunities and significant risks,” stated Curtis Dukes, Executive Vice President and General Manager of Security Best Practices at CIS. “By partnering with Astrix and Cequence, we are ensuring that organizations have the tools they need to adopt AI responsibly and securely.”

Strengthening AI Ecosystems

Astrix's role centers on enhancing the security of AI agents, MCP servers, and Non-Human Identities (NHIs)—elements like API keys, service accounts, and OAuth tokens—that connect them to vital systems. "AI agents and the non-human identities that power them bring great potential but also new risks," said Jonathan Sander, Field CTO of Astrix Security.

"Our focus is helping enterprises discover, secure, and deploy AI agents responsibly, with the confidence to scale. Through this partnership, we’re providing clear, practical guidance to keep AI ecosystems safe so organizations can innovate with confidence."

API Security Expertise

Cequence contributes its extensive experience in enterprise application and API security

Cequence contributes its extensive experience in enterprise application and API security to the improvement of agentic AI security.

“As organizations embrace agentic AI, trust hinges on visibility, governance, and control over what those agents can see and do to your applications and data,” remarked Ameya Talwalkar, CEO of Cequence Security. “Security is strongest through collaboration, and this partnership gives organizations clear guidance to adopt AI safely and securely.”

Enhancing Cybersecurity Frameworks

The alliance aims to extend trusted cybersecurity frameworks into AI environments, addressing risks from autonomous systems and integrations. It pledges to deliver clear and prioritized safeguards, guiding enterprises towards secure and responsible AI adoption. Scheduled for release in early 2026, the new guidance will be supported by workshops, webinars, and additional resources provided jointly by CIS, Astrix, and Cequence.

Through this collaboration, the organizations intend to assist enterprises in applying recommendations practically, establishing a solid foundation of trust, transparency, and resilience across the AI ecosystem. By adhering to a unified framework, enterprises, vendors, and security leaders can synchronize on a common language for securing AI environments.

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The Center for Internet Security, Inc. (CIS®), Astrix Security, and Cequence Security now announced a strategic partnership to develop new cybersecurity guidance tailored to the unique risks of artificial intelligence (AI) and agentic systems. 

This collaborative initiative builds on the globally recognized CIS Critical Security Controls® (CIS Controls®), extending its principles into AI environments where autonomous decision‑making, tool and API access, and automated threats introduce new challenges. The intent of the partnership includes initially developing two CIS Controls companion guides: one for AI Agent Environments, which will focus on securing the agent system lifecycle; the other for Model Context Protocol (MCP) environments.

Adopt AI responsibly and securely

MCP environments introduce unique risks, including credential exposure, ungoverned local execution, unapproved third‑party connections, and uncontrolled data flows between models and tools. Together, these guides will provide targeted safeguards for organizations operating in environments where MCP agents, tools, and registries interact dynamically with enterprise systems. 

“AI presents both tremendous opportunities and significant risks,” said Curtis Dukes, Executive Vice President and General Manager of Security Best Practices at CIS. “By partnering with Astrix and Cequence, we are ensuring that organizations have the tools they need to adopt AI responsibly and securely.”

 AI ecosystems

Astrix’s contribution centres on securing AI agents, MCP servers, and the Non‑Human Identities (NHIs), such as API keys, service accounts, and OAuth tokens, that link them to critical systems. 

“AI agents and the non‑human identities that power them bring great potential but also new risks,” said Jonathan Sander, Field CTO of Astrix Security. “Our focus is helping enterprises discover, secure, and deploy AI agents responsibly, with the confidence to scale. Through this partnership, we’re providing clear, practical guidance to keep AI ecosystems safe so organizations can innovate with confidence.” 

API security experience

Cequence brings years of enterprise application and API security experience to agentic AI enablement and security.

“As organizations embrace agentic AI, trust hinges on visibility, governance, and control over what those agents can see and do to your applications and data,” said Ameya Talwalkar, CEO of Cequence Security. “Security is strongest through collaboration, and this partnership gives organizations clear guidance to adopt AI safely and securely.” 

How the partnership supports organizations 

  • Extends trusted cybersecurity frameworks into AI environments, addressing risks from autonomous systems and integrations. 
  • Delivers clear, prioritised safeguards that guide enterprises toward secure and responsible AI adoption. 

Resilience across the AI ecosystem

Combines expertise across standards, API security, and application defense to provide comprehensive protection. The new guidance is scheduled for release in early 2026, accompanied by workshops, webinars, and supporting resources delivered jointly by CIS, Astrix, and Cequence.

Together, the organizations aim to help enterprises translate recommendations into practice while building a stronger foundation of trust, transparency, and resilience across the AI ecosystem. By working from a shared framework, enterprises, vendors, and security leaders can align on a common language for securing AI environments.

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